--- product_id: 59314981 title: "Supplements, P-5-P 50 mg with Coenzyme B-6 + Mg Bisglycinate, 90 Veg Capsules" brand: "now foods" price: "£15.60" currency: GBP in_stock: true reviews_count: 10 category: "Now Foods" url: https://www.desertcart.co.uk/products/59314981-supplements-p-5-p-50-mg-with-coenzyme-b-6 store_origin: GB region: United Kingdom --- # 50 mg P-5-P active B-6 Supports neurotransmitter & brain health Mg Bisglycinate for enhanced absorption Supplements, P-5-P 50 mg with Coenzyme B-6 + Mg Bisglycinate, 90 Veg Capsules **Brand:** now foods **Price:** £15.60 **Availability:** ✅ In Stock ## Summary > ⚡ Elevate your brain & body game with NOW’s bioactive B-6 boost! ## Quick Answers - **What is this?** Supplements, P-5-P 50 mg with Coenzyme B-6 + Mg Bisglycinate, 90 Veg Capsules by now foods - **How much does it cost?** £15.60 with free shipping - **Is it available?** Yes, in stock and ready to ship - **Where can I buy it?** [www.desertcart.co.uk](https://www.desertcart.co.uk/products/59314981-supplements-p-5-p-50-mg-with-coenzyme-b-6) ## Best For - now foods enthusiasts ## Why This Product - Trusted now foods brand quality - Free international shipping included - Worldwide delivery with tracking - 15-day hassle-free returns ## Key Features - • **Magnesium Synergy:** Mg Bisglycinate enhances absorption and supports nervous system balance. - • **Daily Wellness Ritual:** One capsule a day keeps inflammation and fatigue at bay—perfect for busy professionals. - • **Neuro & Energy Catalyst:** Boosts neurotransmitter function and energy metabolism for sharper focus and vitality. - • **Bioactive B-6 Powerhouse:** Skip liver conversion with P-5-P for instant, potent vitamin B-6 support. - • **Clean, Certified Quality:** GMP A-rated, third-party tested for purity, potency, and vegan-friendly formulation. ## Overview NOW Foods P-5-P 50 mg capsules deliver vitamin B-6 in its active coenzyme form, bypassing liver conversion for superior bioavailability. Enhanced with magnesium bisglycinate, this vegan-friendly supplement supports energy metabolism, neurotransmitter function, and nervous system health. Manufactured under strict GMP standards, it’s a trusted daily ally for reducing inflammation and optimizing cognitive and physical performance. ## Description Coenzyme B-6 + Mg Bisglycinate Vitamin B-6 (pyridoxine) acts primarily as an enzyme catalyst in many body processes including energy metabolism and neurotransmitter function.* Before it can be used for this purpose it must be converted into its coenzyme form (P-5-P) by the liver. P-5-P eliminates this step by providing B-6 in its converted form, allowing for greater bioavailability. Natural color variation may occur in this product. Review: Helped reduce inflammation in my hands - [+] WHITE GLOVE REVIEW [w/ VIDEO] I use this product to reduce inflammation in my hands. In the morning, my hands started to become inflamed. They felt bloated/puffy, it was difficult to move my fingers, my joints hurt a little bit, and they were stiff (i.e., not flexible). They didn't look swollen, they just felt that way. This happened when I woke up, but then they would return to normal during the day as I became active. Sometimes I only felt the effects for 5-10 minutes, and sometimes it lasted for hours. I have a background in nutrition, so I realized this could be a symptom of systemic inflammation. I know of two good causes of systemic inflammation, which are an imbalance of Omega-3 to Omega-6's and high homocysteine levels. I tried taking extra fish oil to help balance out my Omega-3 to -6 ratio, but that didn’t help. I was already taking extra B-12 and Folate, but I was not taking extra B-6. All three are needed to regulate homocysteine levels. I started taking Now P-5-P along with B-12 and Folate. The next morning, I felt a noticeable (about 50%) improvement. I kept taking all three once a day in the evening. Each day I noticed more improvement. It took somewhere between 1-2 weeks before my symptoms were about 95% gone. Eventually, all my symptoms disappeared (I didn’t keep track of how long it took). Now, when I wake up in the morning, my hands have no discomfort and work like normal (i.e., no inflammation and perfectly flexible). [+] HOMOCYSTEINE CYCLE The important thing to note is that all three (B-6, B-12, and Folate) need to be taken. Remember, I was taking two of the three and I still experienced elevated homocysteine levels. I will include links below for the products I take. It is my opinion that the homocysteine cycle is not very well understood by nutritionists or treated properly as a cause of inflammation. You can google it to find out more about it. Also, it is likely that only an older person might experience this, but there is no reason it might not happen to a younger person as well (just not as likely). [+] USAGE I take all three once per day. The B-6 and Folate can be taken on an empty stomach. The B-12 is taken with a lozenge under the tongue. The B-6 (P-5-P) provides about 33mg. Keep in mind that the upper limit for B-6 is 100mg per day. Therefore, I take 1 or 2 per day at the most if I have symptoms, and I only take 1 per day for maintenance. There are days that I skip it all together, and I am fine as long as I do not go too long without taking the vitamins. One time I went too long (over a week) without and the inflammation started to return. I started taking the vitamins again, and the symptoms disappeared right away. The B-12 and Folate have no upper limit, so you can take more, but I have found that one per day is sufficient. Warning: This form of Folate IS NOT Folic Acid. Folic Acid does have an upper limit and ingesting too much Folic Acid in foods or supplements can be problematic as noted by some studies. It is worth noting that I also take a high-quality multi-vitamin, which contains B-6, B-12 and Folic Acid. As we age, there are some situations where a therapeutic dose might be needed, which means that the amounts in the multi-vitamin are not enough. It’s not that the multi-vitamin has an incorrect dose; it’s that my needs require a higher dose for these three vitamins. [+] PRODUCTS (other than this one) NOW Methyl B-12 1,000 mcg,100 Lozenges (My Review: https://amzn.to/2Cmc73R) Now Methyl Folate, 1000 mcg, 90 Tablets This one was talked about in the video: Source Naturals MegaFolinic 800mcg - 120 Tablets The multi-vitamin I take is: NOW Foods Adam™ Men's Multiple Vitamin - 180 Softgels (My Review: https://amzn.to/2M7Jb45) GIVE Reviews - my standard for writing reviews [G]enuine - Honest, trustworthy review intended to help people in the desertcart family. [I]nformational - Provide information related to this product in a concise matter. [V]aluable - Provide value to the reader to help determine if this product is for them. [E]nlightening - This review needs to go beyond product information such that the reader learns something they did not otherwise know. [+] Where is the VIDEO & HELPFUL button? If you are viewing in a pop-up window after clicking the photo, then the video and helpful button will not show. To watch the video or up-vote the review, access the review's page using the following link: https://amzn.to/2QAH3lF ps. remember to up-vote if you like this review or you think this review will help others. Review: Excellent product from a company I TRUST. - A P-5-P supplement is the biologically active, ready-to-use form of Vitamin B6... but you likely already know that if you're considering this purchase. How do we now the quality of ANY supplement we're buying? We can look for 3rd party testing certifications. We can look at the reviews of other users. And we can look at the reputation of the manufacturer. That's why I give this product 5 stars. NOW Foods Supplements was founded over half a century ago. They remain family- and employee-owned, and are based in the USA. They buy raw materials from vendors worldwide and then test, mix, and bottle them in the United States, at their plants in Indiana and Nevada. They aren't the cheapest brand out there, but their combination of excellent products at a reasonable price is unsurpassed. Reality: When it comes to supplements and vitamins, it all comes down to trusting the manufacturer. I trust NOW Foods products. ## Features - ENZYME CATALYST*: Vitamin B-6 (pyridoxine) acts primarily as an enzyme catalyst in many body processes including energy metabolism and neurotransmitter function* - SUGGESTED USAGE: Take 1 capsule daily with a meal - CONVERTED FORM: Before it can be used for this purpose it must be converted into its coenzyme form (P-5-P) by the liver. P-5-P eliminates this step by providing B-6 in its converted form, allowing for greater bioavailability - GMP Quality Assured: A-rated, third-party certification means that every aspect of the NOW manufacturing process has been examined. Our in-house laboratories are ISO/IEC accredited for laboratory testing including for stability, potency and product formulation. - Founded in 1968 by Elwood Richard, NOW is one of the largest independent, family- and employee-owned manufacturers of natural products ## Technical Specifications | Specification | Value | |---------------|-------| | ASIN | B0753G21CW | | Age Range Description | Adult | | Allergen Information | Allergen-Free | | Best Sellers Rank | #24,381 in Health & Household ( See Top 100 in Health & Household ) #723 in Blended Vitamin & Mineral Supplements | | Brand | NOW Foods | | Brand Name | NOW Foods | | Color | Pale Yellow W/Speckles | | Container Type | Bottle | | Customer Reviews | 4.6 out of 5 stars 1,603 Reviews | | Diet Type | Halal, Kosher, Vegan, Vegetarian | | Dosage Form | Capsule | | Flavor | Unflavored | | Global Trade Identification Number | 00733739004611 | | Item Dimensions | 1.95 x 1.95 x 4.3 inches | | Item Form | Capsule | | Manufacturer | NOW Sports - Nutrition and Wellness | | Manufacturer Part Number | 0461 | | Model Name | upplements, P-5-P 50 mg with Coenzyme B-6 + Mg Bisglycinate, 90 Veg Capsules | | Model Number | 0461 | | Number of Items | 1 | | Primary Supplement Type | B-Complex | | Product Benefits | Brain Health Support | | Special Ingredients | P-5-P (pyridoxal-5-phosphate) 50 mg | | Specific Uses For Product | Nervous System Support | | Supplement Formulation | Individual Supplement | | UPC | 733739004611 | | Unit Count | 90 Count | ## Product Details - **Brand:** NOW Foods - **Diet Type:** Halal, Kosher, Vegan, Vegetarian - **Flavor:** Unflavored - **Item Form:** Capsule - **Primary Supplement Type:** B-Complex ## Images ![Supplements, P-5-P 50 mg with Coenzyme B-6 + Mg Bisglycinate, 90 Veg Capsules - Image 1](https://m.media-amazon.com/images/I/71aVJnJbsLL.jpg) ## Available Options This product comes in different **Size** options. ## Questions & Answers **Q: what is p5p vititam** A: Vitamin B-6 (pyridoxine) acts primarily as an enzyme catalyst in many body processes including energy metabolism and neurotransmitter function. Before it can be used for this purpose it must be converted into its coenzyme form (P-5-P) by the liver. P-5-P eliminates this step by providing B-6 in its converted form, allowing for greater bioavailability. **Q: is this the activated form of b6?** A: yes it is **Q: The product clearly says on the back 33 mg of p-5-p and 25 mg of magnesium. so where does the 50 mg of p5p listed on the front come from?** A: The back of mine says: " 33 mg of B-6 [from 50 mg Coenzyme Pyridoxal-5-Phosphate P-5-P) monohydrate]". So it has 50 mg of P-5-P which provides an equivalent 33mg of vitamin B-6. **Q: Dos anyone know why NOW mixed the P5P with Mg bisglycinate? what is the benefit?** A: I can’t remember the reasoning, you’ll need to research. With that being said, it’s more beneficial from what I remember ## Customer Reviews ### ⭐⭐⭐⭐⭐ Helped reduce inflammation in my hands *by G***S on November 27, 2018* [+] WHITE GLOVE REVIEW [w/ VIDEO] I use this product to reduce inflammation in my hands. In the morning, my hands started to become inflamed. They felt bloated/puffy, it was difficult to move my fingers, my joints hurt a little bit, and they were stiff (i.e., not flexible). They didn't look swollen, they just felt that way. This happened when I woke up, but then they would return to normal during the day as I became active. Sometimes I only felt the effects for 5-10 minutes, and sometimes it lasted for hours. I have a background in nutrition, so I realized this could be a symptom of systemic inflammation. I know of two good causes of systemic inflammation, which are an imbalance of Omega-3 to Omega-6's and high homocysteine levels. I tried taking extra fish oil to help balance out my Omega-3 to -6 ratio, but that didn’t help. I was already taking extra B-12 and Folate, but I was not taking extra B-6. All three are needed to regulate homocysteine levels. I started taking Now P-5-P along with B-12 and Folate. The next morning, I felt a noticeable (about 50%) improvement. I kept taking all three once a day in the evening. Each day I noticed more improvement. It took somewhere between 1-2 weeks before my symptoms were about 95% gone. Eventually, all my symptoms disappeared (I didn’t keep track of how long it took). Now, when I wake up in the morning, my hands have no discomfort and work like normal (i.e., no inflammation and perfectly flexible). [+] HOMOCYSTEINE CYCLE The important thing to note is that all three (B-6, B-12, and Folate) need to be taken. Remember, I was taking two of the three and I still experienced elevated homocysteine levels. I will include links below for the products I take. It is my opinion that the homocysteine cycle is not very well understood by nutritionists or treated properly as a cause of inflammation. You can google it to find out more about it. Also, it is likely that only an older person might experience this, but there is no reason it might not happen to a younger person as well (just not as likely). [+] USAGE I take all three once per day. The B-6 and Folate can be taken on an empty stomach. The B-12 is taken with a lozenge under the tongue. The B-6 (P-5-P) provides about 33mg. Keep in mind that the upper limit for B-6 is 100mg per day. Therefore, I take 1 or 2 per day at the most if I have symptoms, and I only take 1 per day for maintenance. There are days that I skip it all together, and I am fine as long as I do not go too long without taking the vitamins. One time I went too long (over a week) without and the inflammation started to return. I started taking the vitamins again, and the symptoms disappeared right away. The B-12 and Folate have no upper limit, so you can take more, but I have found that one per day is sufficient. Warning: This form of Folate IS NOT Folic Acid. Folic Acid does have an upper limit and ingesting too much Folic Acid in foods or supplements can be problematic as noted by some studies. It is worth noting that I also take a high-quality multi-vitamin, which contains B-6, B-12 and Folic Acid. As we age, there are some situations where a therapeutic dose might be needed, which means that the amounts in the multi-vitamin are not enough. It’s not that the multi-vitamin has an incorrect dose; it’s that my needs require a higher dose for these three vitamins. [+] PRODUCTS (other than this one) NOW Methyl B-12 1,000 mcg,100 Lozenges (My Review: https://amzn.to/2Cmc73R) Now Methyl Folate, 1000 mcg, 90 Tablets This one was talked about in the video: Source Naturals MegaFolinic 800mcg - 120 Tablets The multi-vitamin I take is: NOW Foods Adam™ Men's Multiple Vitamin - 180 Softgels (My Review: https://amzn.to/2M7Jb45) GIVE Reviews - my standard for writing reviews [G]enuine - Honest, trustworthy review intended to help people in the Amazon family. [I]nformational - Provide information related to this product in a concise matter. [V]aluable - Provide value to the reader to help determine if this product is for them. [E]nlightening - This review needs to go beyond product information such that the reader learns something they did not otherwise know. [+] Where is the VIDEO & HELPFUL button? If you are viewing in a pop-up window after clicking the photo, then the video and helpful button will not show. To watch the video or up-vote the review, access the review's page using the following link: https://amzn.to/2QAH3lF ps. remember to up-vote if you like this review or you think this review will help others. ### ⭐⭐⭐⭐⭐ Excellent product from a company I TRUST. *by P***W on June 7, 2026* A P-5-P supplement is the biologically active, ready-to-use form of Vitamin B6... but you likely already know that if you're considering this purchase. How do we now the quality of ANY supplement we're buying? We can look for 3rd party testing certifications. We can look at the reviews of other users. And we can look at the reputation of the manufacturer. That's why I give this product 5 stars. NOW Foods Supplements was founded over half a century ago. They remain family- and employee-owned, and are based in the USA. They buy raw materials from vendors worldwide and then test, mix, and bottle them in the United States, at their plants in Indiana and Nevada. They aren't the cheapest brand out there, but their combination of excellent products at a reasonable price is unsurpassed. Reality: When it comes to supplements and vitamins, it all comes down to trusting the manufacturer. I trust NOW Foods products. ### ⭐⭐⭐⭐⭐ The Little Capsule That Could *by M***X on November 27, 2025* NOW Foods P 5 P 50 mg with Coenzyme B 6 and Magnesium Bisglycinate has quietly become one of the most effective supplements in my daily routine. I originally bought it to help with energy and mood, but the combination in this formula delivers benefits in more areas than I expected. Within the first week, I noticed a smoother, more stable kind of energy. Not hyped up, just “I can actually start my day without dragging myself around” energy. One morning really stood out. I had barely slept, fully expecting a rough start, but after taking my usual capsule, I felt surprisingly steady and clear headed. It was the first moment I thought, “Okay, this stuff is definitely doing something.” The mood support has been even more noticeable. There were a couple of afternoons when I would normally hit my classic cranky slump, but instead I felt calm and centered. The B 6 in its active form seems to kick in reliably, and the magnesium bisglycinate helps take the edge off tension without making me sleepy. I also appreciated a smaller but very real benefit. I get mild muscle twitching sometimes when I’m stressed or dehydrated, and after a week or two on this supplement those little twitches became much less frequent. That alone felt like a win. The capsules are easy on the stomach and gentle enough to take daily. No weird aftertaste, no noticeable side effects, just consistent support that builds. If you want a supplement that helps with energy, mood, stress, muscle comfort, and overall clarity, this is an excellent choice. NOW Foods delivered a thoughtful, well balanced formula here. Truly a five star product. ## Frequently Bought Together - NOW Foods Supplements, P-5-P 50 mg with Coenzyme B-6 + Mg Bisglycinate, 90 Veg Capsules - NOW Foods Supplements, Methyl Folate 1,000 mcg, Metabolically Active Folate*, Co-Enzyme B Vitamin, 90 Tablets - NOW Foods Supplements, Methyl B-12 (Methylcobalamin) 1,000 mcg, Nervous System Health*, 100 Lozenges --- ## Why Shop on Desertcart? - 🛒 **Trusted by 1.3+ Million Shoppers** — Serving international shoppers since 2016 - 🌍 **Shop Globally** — Access 737+ million products across 21 categories - 💰 **No Hidden Fees** — All customs, duties, and taxes included in the price - 🔄 **15-Day Free Returns** — Hassle-free returns (30 days for PRO members) - 🔒 **Secure Payments** — Trusted payment options with buyer protection - ⭐ **TrustPilot Rated 4.5/5** — Based on 8,000+ happy customer reviews **Shop now:** [https://www.desertcart.co.uk/products/59314981-supplements-p-5-p-50-mg-with-coenzyme-b-6](https://www.desertcart.co.uk/products/59314981-supplements-p-5-p-50-mg-with-coenzyme-b-6) --- *Product available on Desertcart United Kingdom* *Store origin: GB* *Last updated: 2026-06-20*