---
product_id: 4077382
title: "SAMe 400"
brand: "jarrow formulas"
price: "£39.80"
currency: GBP
in_stock: true
reviews_count: 8
category: "Jarrow Formulas"
url: https://www.desertcart.co.uk/products/4077382-same-400
store_origin: GB
region: Great Britain
---

# 400 mg potent active S,S form Joint & liver health support Supports brain metabolism & mood balance SAMe 400

**Brand:** jarrow formulas
**Price:** £39.80
**Availability:** ✅ In Stock

## Summary

> 💡 Elevate your mind, mood & mobility — naturally unstoppable!

## Quick Answers

- **What is this?** SAMe 400 by jarrow formulas
- **How much does it cost?** £39.80 with free shipping
- **Is it available?** Yes, in stock and ready to ship
- **Where can I buy it?** [www.desertcart.co.uk](https://www.desertcart.co.uk/products/4077382-same-400)

## Best For

- jarrow formulas enthusiasts

## Why This Product

- Trusted jarrow formulas brand quality
- Free international shipping included
- Worldwide delivery with tracking
- 15-day hassle-free returns

## Key Features

- • **Clean & Pure Formula:** Non-GMO, vegan, allergen-free—perfect for mindful health enthusiasts
- • **30-Day Supply Convenience:** One tablet daily regimen fits seamlessly into busy professional lifestyles
- • **Trusted Quality by Jarrow:** Backed by science and rave reviews for natural mood and cognitive support
- • **Multi-Dimensional Wellness:** Supports joint comfort, liver detox, brain metabolism, and mood stability
- • **Clinically Potent 400 mg Dose:** High concentration of bioactive S,S SAMe for maximum efficacy

## Overview

Jarrow Formulas SAMe Supplement delivers a potent 400 mg dose of the active S,S form of SAMe, a naturally occurring compound essential for joint health, liver function, brain metabolism, and mood balance. This clean, vegan-friendly formula is free from common allergens and designed for daily use, offering 30 servings per bottle. Trusted by thousands, it’s a scientifically backed choice for professionals seeking holistic mental and physical wellness.

## Description

Buy Jarrow Formulas SAMe Supplement 400 mg - 30 Tablets - High Concentration of Active S,S Form - Supports Joint Health, Liver Function, Brain Metabolism, Balanced Mood & Antioxidant Defense - 30 Servings on desertcart.com ✓ FREE SHIPPING on qualified orders

Review: I am so amazed with this product - I have used desertcart for almost 10 years and I've never written a review because I'm just not the type to do so, nor do I have the time or energy to put in the effort. However, I am so amazed with this product, I have a burning desire to share my positive experience. First of all, I have tried EVERYTHING to help depression. Seriously. I've always experienced prescription drugs to be too much for my system no matter the dosing and the time I waiting the side effect out. With Sam-e, I started out taking 400s right as I woke up. (30 min before breakfast.) The first 5-6 days, I experienced heightened anxiety and insomnia. I remember one night just wide eyed thinking that it was ridiculous that I couldn't sleep. After about 5-6 days, I started to sleep normal again and the anxiety tapered off. Before I even realized it, I was just level. It's hard to explain. The edge was taken off. I've been really stressed out and depressed, and I'm in my second year of nursing school. Now, 2 months on Sam-e, the stress is minimal because I am able to control my perception on situations and life so much better. Control is something I've never had with my emotions or mental being. I've struggled with a little OCD, depression to where I wouldn't leave the house, sometimes not get out of bed and I would sit in my car for hours because I just felt like I couldn't move. I wouldn't even go into a grocery store because I didn't feel confident to deal with people or strangers. Sam-e has saved my life! That sounds so cliché but I am being as authentic as I can here. I don't feel like I'm on anything and I have zero side effects. I've not felt like I needed to adjust my dosing, as some people feel they need to bump up to higher doses to feel more of an affect. I did do a lot of research before taking Sam-e and I do take folic acid and a B complex. Apparently, those two supplements prevent a certain chemical from building up in your body from taking Sam-e. All in all, I am just so grateful to be one of the 5 star reviewers. I remember reading these same reviews praying that Sam-e would be a miracle for me and it is! My best advice is it doesn't hurt to try. Give it time.. If you feel the anxiety and insomnia, just hang in there. And take the folic acid and b complex with it; maybe that makes a difference. Wish you the best!
Review: Better than an anti-depressant. - For years, I was placed on chemical anti-depressants that masked my symptoms, but gave me horrid side effects and no other benefits besides lifting my mood a bit. SAM-e is a naturally occurring compound. Many people that are diagnosed with depression simply do not produce enough SAM-e naturally (whether due to genetics, poor diet, etc...) and SAM-e is all they need to see relief. I threw my anti-depressants in the garbage one day and went through horrible withdrawals. I was having a lot of difficulty and needed something that could help. I scoured the internet for natural solutions and came upon this. Everywhere I looked, they said that Jarrow Formulas was the best quality available. Within a week of taking SAM-e, I could function. Things were looking up. I was me again. That was two summers ago and would not be without it since. Here's the kicker: I recently found out I have MTHFR which is (quoting from a site so that I can explain it properly) "a genetic mutation where homocysteine levels are too high in the brain due to the fact that not enough Methylfolate is available to convert the homocysteine into Methionine, SAMe and Glutathione. Methylfolate (L-MTHF or 5-MTHF) is like a wizard changing the bad guy (Homocysteine) into good guys (SAMe and Glutathione)." So it turns out I have a medical lack of SAM-e. Also, those with MTHFR can find themselves with high folate or high B12. i.e. the body will have problems converting inactive forms of folate and B12 (like those in normal multivitamins/enriched foods) to the active forms. So the inactive folate or B12 will simply build up in your serum, also inhibiting the active forms. Ultimately, this = vitamin b12 deficiency, because everything is inhibited. MTHFR is linked to Fibromyalgia, Chronic Fatigue Syndrome, Migraines, IBS, Depression, and Alzheimer's. Alzheimer's runs in my family. Recent studies have shown that "a line of evidence suggested abnormally low levels of endogenous SAM (S-Adenosyl methionine) may play an important role in the development of Alzheimer's disease, and that SAM may therefore have therapeutic potential in the treatment of Alzheimer's disease." Other research has said "this effect is likely due to vitamin B12 deficiencies, which result in neurologic defects due to the inability to conduct one carbon transfers (with folate) in the absence of B12." I also have IBS, and SAM-e seems to help incredibly. I notice if I forget a dose. I take for my mind, my mood, my brain, and hopefully protect myself from Alzheimer's if the studies I have quoted and researched for so long are true! I love Jarrow Formulas because this SAM-e is great quality and at a reasonable price. --Anyone that is sick often or has the symptoms of MTHFR, please look into it! A simple blood test shows it.

## Features

- Heart Health Supplements: this Coenzyme Q10 and Red Yeast Rice supplement supports cardiovascular health (1)
- CoQ10 for Heart Health: Each serving offers red yeast rice 1200 mg plus CoQ10 100mg (1)
- Red Yeast Rice & Co Q10 Supplement: Jarrow Red Yeast Rice with CoQ10 provides cardiovascular support (1)
- Red Rice Yeast with CoQ10 supplement: This formula is non-GMO; gluten-free, wheat-free, soy-free, dairy-free, egg-free, fish/shellfish-free, peanuts/tree nuts and sesame-free
- Convenient Veggie Capsules: As a dietary supplement, adults take 2 capsules per day with a meal or a glass of water, or as directed by your qualified health care consultant

## Technical Specifications

| Specification | Value |
|---------------|-------|
| ASIN | B0013OSJU0 |
| Age Range Description | Adult |
| Allergen Information | Dairy Free, Egg Free, Gluten Free, Soy Free, Wheat Free |
| Best Sellers Rank | #25,323 in Health & Household ( See Top 100 in Health & Household ) #596 in Multi-Enzyme Nutritional Supplements #1,934 in Sales & Deals #9,096 in Diet & Sports Nutrition |
| Brand | Jarrow Formulas |
| Brand Name | Jarrow Formulas |
| Color | White |
| Container Type | Bottle |
| Customer Reviews | 4.2 out of 5 stars 1,325 Reviews |
| Diet Type | Vegetarian |
| Dosage Form | 400 mg |
| Flavor | Unflavored |
| Global Trade Identification Number | 00790011200208 |
| Item Dimensions | 2 x 3 x 5 inches |
| Item Form | Tablet |
| Item Weight | 0.13 Pounds |
| Manufacturer | Jarrow Formulas |
| Manufacturer Part Number | P30525 |
| Material Features | Dairy Free, Egg Free, GMO Free, Gluten Free, Nut Free, Shellfish Free, Vegan |
| Model Name | SAMe 400 |
| Model Number | P30525 |
| Number of Items | 1 |
| Primary Supplement Type | Vitamin |
| Product Benefits | Brain Health Support |
| Special Ingredients | Amino Acid, Lecithin |
| Total Servings Per Container | 30 |
| UPC | 790011200208 |
| Unit Count | 30.0 Count |

## Product Details

- **Brand:** Jarrow Formulas
- **Flavor:** Unflavored
- **Primary Supplement Type:** Vitamin
- **Unit Count:** 30.0 Count
- **Item Form:** Tablet
- **Item Weight:** 0.13 Pounds
- **Item dimensions L x W x H:** 2 x 3 x 5 inches
- **Special Ingredients:** Amino Acid, Lecithin
- **Diet Type:** Vegetarian
- **Product Benefits:** Brain Health Support

## Images

![SAMe 400 - Image 1](https://m.media-amazon.com/images/I/712gkRyqlDL.jpg)

## Questions & Answers

**Q: Does this one hace mannitol in it?**
A: I don't know why this has mannitol, but I suspect many who have GI reactions to this supplement are actually reacting to the mannitol, as it can be used as a laxative.  I would test myself with a mild mannitol prep before buying a supplement containing mannitol, as you may have to discard an expensive supplement.

**Q: Does anyone make a brand with no Mannitol and no Titanium dioxide with a butanedisulfonate form in enteric-coated tablets?**
A: Yep, Azendus does and for a while now they've been the only company in the U.S. that has the patent to make the butanedisulfonate version after GNC's expired. Butanedisulfonate is the formula used in SAM-e clinical studies for treating depression.

**Q: Other ingredients?  Most supplements contain a lot of other ingredients besides the SAM-3 which I do NOT want to be exposed to.  Ingredients, please?**
A: Other Ingredients: Cellulose, silicon dioxide, glyceryl behenate, magnesium stearate (vegetable source), enteric coating (methacrylate copolymers), titanium dioxide, magnesium silicate, triethylcitrate, riboflavin, glycerol palmitostearate, medium chain triglycerides, carboxymethyl starch sodium salt and mannitol.Suitable for vegetarians/vegans.

**Q: How come a month later I feel no effect whatsoever with any of the benefits it provides?**
A: We recommend to discuss your health goals with your doctor and proceed with their guidance. Establishing the most effective dose may require trial and error, along with supervision, depending on your specific goals.

## Customer Reviews

### ⭐⭐⭐⭐⭐ I am so amazed with this product
*by W***0 on October 23, 2015*

I have used Amazon for almost 10 years and I've never written a review because I'm just not the type to do so, nor do I have the time or energy to put in the effort. However, I am so amazed with this product, I have a burning desire to share my positive experience. First of all, I have tried EVERYTHING to help depression. Seriously. I've always experienced prescription drugs to be too much for my system no matter the dosing and the time I waiting the side effect out. With Sam-e, I started out taking 400s right as I woke up. (30 min before breakfast.) The first 5-6 days, I experienced heightened anxiety and insomnia. I remember one night just wide eyed thinking that it was ridiculous that I couldn't sleep. After about 5-6 days, I started to sleep normal again and the anxiety tapered off. Before I even realized it, I was just level. It's hard to explain. The edge was taken off. I've been really stressed out and depressed, and I'm in my second year of nursing school. Now, 2 months on Sam-e, the stress is minimal because I am able to control my perception on situations and life so much better. Control is something I've never had with my emotions or mental being. I've struggled with a little OCD, depression to where I wouldn't leave the house, sometimes not get out of bed and I would sit in my car for hours because I just felt like I couldn't move. I wouldn't even go into a grocery store because I didn't feel confident to deal with people or strangers. Sam-e has saved my life! That sounds so cliché but I am being as authentic as I can here. I don't feel like I'm on anything and I have zero side effects. I've not felt like I needed to adjust my dosing, as some people feel they need to bump up to higher doses to feel more of an affect. I did do a lot of research before taking Sam-e and I do take folic acid and a B complex. Apparently, those two supplements prevent a certain chemical from building up in your body from taking Sam-e. All in all, I am just so grateful to be one of the 5 star reviewers. I remember reading these same reviews praying that Sam-e would be a miracle for me and it is! My best advice is it doesn't hurt to try. Give it time.. If you feel the anxiety and insomnia, just hang in there. And take the folic acid and b complex with it; maybe that makes a difference. Wish you the best!

### ⭐⭐⭐⭐⭐ Better than an anti-depressant.
*by O***A on September 23, 2013*

For years, I was placed on chemical anti-depressants that masked my symptoms, but gave me horrid side effects and no other benefits besides lifting my mood a bit. SAM-e is a naturally occurring compound. Many people that are diagnosed with depression simply do not produce enough SAM-e naturally (whether due to genetics, poor diet, etc...) and SAM-e is all they need to see relief. I threw my anti-depressants in the garbage one day and went through horrible withdrawals. I was having a lot of difficulty and needed something that could help. I scoured the internet for natural solutions and came upon this. Everywhere I looked, they said that Jarrow Formulas was the best quality available. Within a week of taking SAM-e, I could function. Things were looking up. I was me again. That was two summers ago and would not be without it since. Here's the kicker: I recently found out I have MTHFR which is (quoting from a site so that I can explain it properly) "a genetic mutation where homocysteine levels are too high in the brain due to the fact that not enough Methylfolate is available to convert the homocysteine into Methionine, SAMe and Glutathione. Methylfolate (L-MTHF or 5-MTHF) is like a wizard changing the bad guy (Homocysteine) into good guys (SAMe and Glutathione)." So it turns out I have a medical lack of SAM-e. Also, those with MTHFR can find themselves with high folate or high B12. i.e. the body will have problems converting inactive forms of folate and B12 (like those in normal multivitamins/enriched foods) to the active forms. So the inactive folate or B12 will simply build up in your serum, also inhibiting the active forms. Ultimately, this = vitamin b12 deficiency, because everything is inhibited. MTHFR is linked to Fibromyalgia, Chronic Fatigue Syndrome, Migraines, IBS, Depression, and Alzheimer's. Alzheimer's runs in my family. Recent studies have shown that "a line of evidence suggested abnormally low levels of endogenous SAM (S-Adenosyl methionine) may play an important role in the development of Alzheimer's disease, and that SAM may therefore have therapeutic potential in the treatment of Alzheimer's disease." Other research has said "this effect is likely due to vitamin B12 deficiencies, which result in neurologic defects due to the inability to conduct one carbon transfers (with folate) in the absence of B12." I also have IBS, and SAM-e seems to help incredibly. I notice if I forget a dose. I take for my mind, my mood, my brain, and hopefully protect myself from Alzheimer's if the studies I have quoted and researched for so long are true! I love Jarrow Formulas because this SAM-e is great quality and at a reasonable price. --Anyone that is sick often or has the symptoms of MTHFR, please look into it! A simple blood test shows it.

### ⭐⭐⭐⭐⭐ Never Disappointed -Buy Quality and Follow Directions
*by R***E on October 5, 2011*

Ever since a vet recommended this product for a geriatric dog, I've used it for numerous elder dogs since then. It is also wonderful presurgery (check with your surgeon of course) and after any kind of stress or recovery. I was a Foster home for a breed rescue for many years and this is part of my arsenal to help dogs get part transition stress. To me, seeing the clear results in dogs negates any thought of a placebo effect. Plus, it's backed by enough peer reviewed studies that vets at least prescribe it with confidence.Not this brand,but I have taken care to ensure that the brand I use matches the $80(!) Prescription quality precisely. Narrow is the one I trust the most, but there are other brands which are also excellent. What you want is: Made in USA. Even from some of our friends I suspect the potency, and from China you may as well plant them in the ground like magic beans. No offense to individuals from China, but supplements sourced from those manufacturers are consistently lacking in actual active ingredient. :( Enteric coating. The active ingredient is absorbed in the colon, so must pass the stomach. It will also give you a massive belly ache! Blister packaging or some other way to seal the tablets individually. The active ingredient is highly volatile. It is sensitive to light, oxygen, heat, and moisture. Also, you want to avoid scratching or chipping the coating. The directions say take on an empty stomach and wait thirty minutes before food. The minute you wake up is the best time. Nothing should be down there triggering extra digestive action. All this is totally worth it. I have three dogs, one twelve,one thirteen, one eighteen. The twelve and thirteen year older still play Frisbee, I mean really play, like jumping and stuff. The eighteen years old still requires her daily walks and training time,or she gets into trouble, countersurfing or removing the kitchen trash from the LOCKED cabinet. The only other thing I do for them in terms of supplements is melatonin at night to ensure correct sleep patterns.

## Frequently Bought Together

- Jarrow Formulas SAMe 400 mg, Supports Joint Health, Liver Function, Brain Metabolism, 30 Tablets, Up To a 30 Day Supply
- Jarrow Formulas Magnesium L-Threonate, MagMind Magtein Brain Supplements for Memory Support, 90 Veggie Capsules, Up to a 30 Day Supply
- Jarrow Formulas® SAMe 200 mg, Supports Joint Health, Liver Function, Brain Metabolism, 60 Tablets, Up To A 60 Day Supply

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*Product available on Desertcart Great Britain*
*Store origin: GB*
*Last updated: 2026-04-26*